Long-term toxicological effects of paracetamol in rats

The analgesic and antipyretic properties of paracetamol were first described in 1893, then it has been widely available as a non-prescription drug, with a therapeutic profile that reflects widespread safety and efficacy as well as paracetamol became the most widely used analgesic and antipyretic in children. It is the most frequently used over-the counter medicine in young children and is nearly universally used in infants. The drug is used by millions of children every day. The study was designed to study the toxicological effect of therapeutic dose of paracetamol after oral administration for three months in laboratory rats (Rattus norvegicous) on the heart, kidney and liver. Results showed oral administration of the paracetamol for three months in laboratory rats showed that this drug has a severe damaging effect on most of the vital organs in the body like kidney, liver and heart

Pilonidal Sinus Management Using 980 nm Diode Laser

Background: Pilonidal sinus is a chronic, debilitating disease of the natal cleft. It mainly involves the sacrococcygeal region and the presentation varies from asymptomatic pits to painful abscesses or sinuses. Treatment options vary from observation to wide excision. Unfortunately, surgical treatment may result in recurrence. Many conservative methods had being described for treatment of pilonidal sinus, photocoagulation using laser is one of them.The aim of study: To assess the efficacy of laser (diode) as a therapy to the pilonidal sinus.Design: A cohort of five patients with a provisional diagnosis of  pilonidal sinus (unbranched) were treated by photocoagulation of sinus tract by diode laser 980 nm, between 17 and 25 year old (20.6±2.58), were diagnosed clinically and by sinogram to know the exact length of the tract and to exclude branching tract. The average length of the tracts were (5 cm) ranging (3-7) cm. Only one patient had recurrent sinus after surgical excision.Result: The mean operative time was (10.10) min. (range of 6.10-14.10 min.). All patient were seen the day after the procedure and then weekly, only one patient had pus discharge at day nine and was treated with ciprofloxacin and metronidazole for ten days and tract closed after 21 days of the procedure. The average time for closure was (10.4) day ranging (6-21).conclusion: Diode laser as a surgical tools in the treatment of pilonidal sinus offers the following benefits: Reducing hospital stay, minimizing tissue assault by avoiding unduly extensive procedures with the attendant complications, early resumption of work by the patient and preventing recurrence of the disease. Keywords: pilonidal, diode 980nm, diode lase

Minimally invasive reduction and percutaneous fixation versus open reduction and internal fixation for displaced intra-articular calcaneal fractures : a systematic review of the literature

The aim of this article is to systematically identify and analyse research evidence available to compare the outcomes of minimally invasive reduction and percutaneous fixation (MIRPF) versus open reduction and internal fixation (ORIF) for displaced intra-articular calcaneal fractures. Articles from 2000 to 2016 were searched through MEDLINE (PubMed), Cochrane Library, Embase, ScienceDirect, Scopus and ISI Web of Knowledge using Boolean logic and text words. Of the 570 articles identified initially, nine were selected including three randomized controlled trials and six retrospective comparative studies. All nine studies had a total of 1,031 patients with 1,102 displaced intra-articular calcaneal fractures. Mean follow-up was 33 months. Of these, 602 (54.6%) were treated with MIRPF and 500 (45.4%) were treated with ORIF. Overall incidence of wound-related complications in patients treated with MIRPF was 4.3% (0% to 13%) compared with 21.2% (11.7% to 35%) in the ORIF group Functional outcomes were reported to be better in the minimally invasive group in all studies; however, the results did not reach statistical significance in some studies. All the studies had methodological flaws that put them at either ‘unclear’ or ‘high’ risk of bias for multiple domains. Overall quality of the available evidence is poor in support of either surgical technique due to small sample size, flaws in study designs and high risk of bias for various elements. Individual studies have reported minimally invasive techniques to be an effective alternative with lower risk of wound complications and better functional outcomes.</ul

SAR-Based Vibration Estimation Using the Discrete Fractional Fourier Transform

A vibration estimation method for synthetic aperture radar (SAR) is presented based on a novel application of the discrete fractional Fourier transform (DFRFT). Small vibrations of ground targets introduce phase modulation in the SAR returned signals. With standard preprocessing of the returned signals, followed by the application of the DFRFT, the time-varying accelerations, frequencies, and displacements associated with vibrating objects can be extracted by successively estimating the quasi-instantaneous chirp rate in the phase-modulated signal in each subaperture. The performance of the proposed method is investigated quantitatively, and the measurable vibration frequencies and displacements are determined. Simulation results show that the proposed method can successfully estimate a two-component vibration at practical signal-to-noise levels. Two airborne experiments were also conducted using the Lynx SAR system in conjunction with vibrating ground test targets. The experiments demonstrated the correct estimation of a 1-Hz vibration with an amplitude of 1.5 cm and a 5-Hz vibration with an amplitude of 1.5 mm

Temperature dependence of the single photon source efficiency based on QD-cQED

We study a photonic circuit consisting of a quantum dot, QD, coupled to a photon cavity over a wide range of temperature up to room temperature. A key component of such a system is presented here in the form of a Purcell-enhanced single-photon source based on Cavity Quantum Electrodynamics, cQED. We use a real set of pure dephasing data extracted from experimental measurements of InGaAs QD to calculate the effective QD-cavity coupling strength, the Purcell factor, and the single photon efficiency emerged from the QD-cavity system in the cases without and with detuning. In the non-detuned system, the effective coupling strength between the QD and the resonator decreases with increasing temperature, results in a decrease in efficiency. However, when the temperature of the QD-cavity system increases under Purcell effect conditions, the detuned QD-cavity system induces spontaneous emission rate enhancement. As a result, we found that the increase in efficiency can be obtained under a certain condition, when the maximum effective coupling strength and the Purcell factor are related to the spontaneous emission and the pure dephasing rates. Additionally, the influences of the pumping mechanism on the efficiency of the QD-system were examined and showed that the pumping process can be used to further increase in efficiency. Our results can be advantageous for advanced quantum optics applications once temperature is taken into account.Comment: RevTeX - pdfLaTeX, 9 pages with 10 included pdf figure

Compressive strength capacity of light gauge steel composite columns

AbstractThe axial compressive strength capacity of concrete-filled light gauge steel composite columns was assessed through an experimental program involving twelve long and fourteen stub columns with width-to-thickness ratio of 125 for the encasing steel section. A comparison between concrete-only and confined stub columns demonstrated that the stub column experiences an increase of strength of up to 16% due to confinement. The compressive strength contribution of the light gauge steel section was limited by local buckling. Specifically, the steel-only stub column sections lacking the concrete core experienced, on average, approximately 33% of its full compressive strength. The full-scale composite columns illustrated that the axial compressive strength capacity was controlled by end bearing capacity and local buckling of the light gauge steel. The axial compression strength capacity of the full-scale composite columns was satisfactorily predicted based on end bearing resistance of the concrete core and local strains in the light gauge steel. Furthermore, the 33% strength contribution established from the steel-only sections provided a satisfactory lower bound estimate for the calculation of axial compressive strength

Hepatic Cryotherapy and Subsequent Hepatic Arterial Chemotherapy for Colorectal Metastases to the Liver

This paper presents an experience of thirty consecutive patients with hepatic colorectal metastases who were treated with hepatic cryotherapy and subsequent hepatic arterial infusion (HAI) chemotherapy using 5FU

Processes of equatorial thermal structure at Jupiter: An analysis of the Galileo temperature profile with a three‐dimensional model

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/94956/1/jgre1925.pd